Sana Ngayong Pasko tells the ill-fated story of retired teacher Remedios (Susan Roces), who suffered terribly during the onslaught of Typhoon Ondoy. With no one to turn to, Remedios begins to yearn for the family she lost years ago. Isang pamilyang nawalay sa kanya dahil sa maling paghihinala ng kanyang asawang si Pablo (Dante Rivero). Sa pagpasok ng Christmas season, ang magiging tanging hiling niya ay ang ma-reunite sa kanyang pamilya. Lalo na ngayon nalaman niya ang tungkol sa kanyang senile dementia—isang sakit kung saan unti-unting nawawala ang mga alaala ng isang tao. Now, more than ever, Remedios needs to show how much she cares for the people she loves, and resolve all their family issues—before her memories disappear forever. In another part of the world, isa nang successful entrepreneur ang panganay na anak ni Remedios: si Gordon (Christopher de Leon). He is the only successful member of the family—and the one who hurt the most nang iwan sila ng kaniyang ina. His sister, Fely (Gina Alajar), has found herself working as a GRO in Macau. Gaya ni Gordon, may tinanim siyang sama ng loob sa kanyang ina, sa pag-iwan sa kanilang magkakapatid. She never forgets the difficulties she had to go through, growing up without the love of a mother. Stephen (TJ Trinidad), meanwhile, becomes a burden para sa pamilya. Sa kanyang pagkalulong sa droga, nahiwalay rin siya sa kanyang asawa—but he was able to get custody of his child. Pero kahit isa siyang single dad, Stephen remains irresponsible. Kaya bang magpatawad ng mga anak na iniwan? Magagawa bang ipaliwanag ni Remedios ang tunay na nangyari ng gabing pinilit niyang lisanin ang pamilyang minahal niya? Bukod sa kuwento ng inang nangungulila sa anak, Sana Ngayong Pasko also presents the story of Rigo (JC de Vera) who longs for the approval of his father Gordon; and the lengths Bernie (JC Tiuseco) would go, para lang makapagbigay ng magandang bukas para kay Elaine (Maxene Magalona). Sana Ngayong Pasko also features Carmina Villaroel, Jomari Yllana, Zoren Legaspi and Mr. Eddie Gutierrez in very special roles. Completing the cast are Ynna Asistio, Janine Desiderio and Jacob Rica. Sana Ngayong Pasko will touch hearts weeknights on GMA Telebabad, pagkatapos ng Full House.