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Rigo's (JC de Vera) kidney donation saves Gordon's (Christopher de Leon) life, prompting a profound change in how Gordon treats his children. Meanwhile, with the truth finally revealed, the entire Dionisio family searches for Remedios (Susan Roces) in the hope of making their family whole again.

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“Sana Ngayong Pasko” is a family drama about a mother striving to reconnect with her family while quietly battling the early stages of dementia.