COVID SCIENCE UPDATE

Two-drug combo improves COVID-19 pneumonia outcomes; Online tool estimates COVID-19 mortality risk

For hospitalized coronavirus disease 2019 (COVID-19) patients with pneumonia, treatment with Gildead Sciences Inc's antiviral remdesivir and the Eli Lilly and Co arthritis drug baricitinib was more effective than remdesivir alone, according to a clinical trial published on Friday in The New England Journal of Medicine.

Overall, the 515 patients who received baricitinib - sold under the brand name Olumiant - along with remdesivir recovered in an average of seven days, compared to eight days for the 518 who got remdesivir alone.

People treated with both drugs also had fewer serious adverse events, plus 30% higher odds of showing improved health status after two weeks.

They also had a lower risk of death within four weeks of starting treatment - 5.1% versus 7.8% with just remdesivir.

The effect was most pronounced among patients who needed high amounts of extra oxygen but were not sick enough to require ventilators to breathe for them.

In this group, the average time to recovery was 10 days with the two-drug treatment compared to 18 days with remdesivir alone.

The study authors note that baricitinib, a pill, is a generally safe drug that does not interact with other medications.

Online tool estimates COVID-19 mortality risk

A new online tool helps to estimate individuals' risk of dying from COVID-19 depending on where they live in the United States, which could provide useful information on which individuals should be prioritized for early vaccinations.

The calculator, developed by Johns Hopkins University researchers, incorporates a variety of factors, including age, race/ethnicity, socioeconomic conditions, underlying medical conditions such as obesity, diabetes or cancer, and local pandemic intensity to produce estimates of adults' COVID-19 mortality risk.

Currently, it does not incorporate information on occupation, such as whether individuals are frontline workers, which may increase risk, said Nilanjan Chatterjee, whose team developed the calculator.

The researchers reported on Friday in Nature Medicine that they found large variations in risk across U.S. cities and counties.

"This information may be helpful for local policy makers to understand the need for vaccine allocations for local communities," Chatterjee said. The calculator is available at https://bit.ly/2LhYsmf. -- Reuters